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Retatrutide Weight Loss: How Much At Each Dose 0:00 Welcome & todays focus: Retatrutide and chasing the biggest number 1:11 On The Pen intro, live schedule (Mon/Wed/Fri) & housekeeping 2:10 How Dave first heard about retatrutide (work trip, early phase 1 data) 3:35 Flashback clip: early excitement about retatrutide phase 3 trials 4:40 Why this new retatrutide data feels different for obesity medicine 5:32 TRIUMPH-4 trial overview: obesity + knee osteoarthritis population 7:00 Headline results: 28.7% average weight loss, surgery-level efficacy 8:47 Breaking down weight loss by dose (9 mg vs 12 mg

School of Immunology and Microbial Sciences, Kings College London, London, United Kingdom

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All analyses were performed using STATA version 14 and R version 3.6.0.)