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Consistent with this, GLP-1R agonism decreases a variety of reward behaviors in rodents, including the motivation to lever press for food reward in an operant conditioning test [746], alcohol intake [747,748], alcohol seeking behavior [747], amphetamine-induced conditioned place preference (Amp-CPP) [748], and hedonic feeding [748]

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GLP-1 receptor agonists were originally developed to improve glycemic control

In the obesity group, there was a significant and clinically meaningful reduction in body weight of 4.74% at week 8, with weight continuously decreasing during the 8-week treatment period
