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The reviews split into three loud camps: people losing 30 to 128 pounds and calling it life-changing, people who quit inside the first month because of nausea, and people who lost nothing at all

Another study published in the Journal of Clinical Endocrinology & Metabolism found that a GLP-1 agonist was effective in reducing body weight and BMI in obese women with PCOS who were also being treated with metformin, a medication commonly used to treat insulin resistance

A useful starting point is the current list price

But if you're going to lose that much weight, a more gradual rate of around 1 to 2 pounds per week is considered safest