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Side effects, particularly nausea and gastrointestinal discomfort are common when starting, but generally improve over time with slow dose escalation

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Each has a different research basis

In a placebo-controlled trial conducted on patients having pre-existing coronary artery disease with preserved left ventricular function, increase in GLP-1 levels caused by DPP-4 inhibition resulted in improvement of global and regional left ventricular function and amelioration of post-ischemic stunning [70]