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Managing semaglutide-induced dry mouth includes practical steps: drinking more water, using a humidifier, avoiding tobacco, caffeine, and alcohol, and using over-the-counter products like mouthwashes and gels

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The Phase 3 TRIUMPH program, ongoing through 2026, is evaluating retatrutide across multiple patient populations: TRIUMPH-1: Adults with obesity without diabetes TRIUMPH-2: Adults with type 2 diabetes TRIUMPH-4: Adults with obesity and knee osteoarthritis TRIUMPH CVOT: Cardiovascular outcomes trial The December 2025 TRIUMPH-4 readout reported an average weight loss of 28.7 percent of body weight at 68 weeks the highest reported weight loss percentage in any obesity drug trial to date