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In bone, GIP promotes bone formation while GLP1 inhibits bone absorption

A 2026 PMC review (PMC 12904723) characterized GLP-1 side effects as follows: GI events are the most prevalent but are "typically transient and dose-dependent." No new safety signals have been identified, and the National Institutes of Health (NIH) continues to fund long-term outcome studies have emerged from long-term data up to 5 years

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The key is knowing exactly what to do when it happens so you do not make the situation worse
