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doi: 10.1002/path.5056

Rare but important risks include pancreatitis, gallbladder problems, dehydration from severe vomiting/diarrhoea, and potential worsening of diabetic eye disease in people with diabetes

(146) observed significant blood-to-brain influx for non-acylated GLP-1 mimetics like exendin-4 and lixisenatide, whereas acylated GLP-1 analogues such as liraglutide and semaglutide showed minimal blood-brain barrier penetration in mice

Geopolitical factors, such as trade agreements, intellectual property rights, and the stability of international supply chains for pharmaceutical ingredients, can also impact the manufacturing and distribution of GLP-1 receptor agonists globally