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Figure 1 from Colhoun , et al, Nat Med 2024 Even if semaglutide saves lives, hearts, and kidneys, and FLOW is a global trial, implementation of the so-called fourth pillar remains a local challenge
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Moreover, the combined GLP-1 mechanisms of weight loss and delayed carbohydrate absorption may also be the key drivers of remission of type 2 diabetes and reduced cardiovascular events found by GLP-1 analogues