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Second, the study identified another genetic variant that is associated with side-effects, specifically nausea and vomiting, while using tirzepatide (Mounjaro or Zepbound)

High-throughput screening campaigns against the GLP-1 receptor and other class B GPCRs consistently yielded low hit rates for small molecules, and the few hits that emerged typically showed micromolar potency, insufficient for therapeutic applications

This is supported by cell-killing assays which indicate increased lysis of NK cell-sensitive lines after GLP-1 treatment, alongside heightened production of IFN- and granzyme B [173]

Flint A, Raben A, Astrup A, and Holst JJ