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"Glucagon-like peptide 1 (GLP-1)." Molecular Metabolism

Creatinine is basically a waste product that your kidneys filter out

Recent studies suggest that tirzepatide may also have direct effects on the blood vessels themselves, potentially through its dual action on GLP-1 and GIP receptors 4,5
Interestingly, while glycosuria and natriuresis persist, osmotic diuresis typically diminishes with continued SGLT2 inhibitor treatment