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Thus, evidence suggests that GLP-1 receptor agonists have a neuroprotective role and can enhance learning and memory, although there is limited research examining effects in females or in middle-aged adults

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For diabetes management, if HbA1c remains above target despite maximal tirzepatide dosing, combination therapy with metformin, SGLT2 inhibitors, or basal insulin should be considered based on individual patient factors and contraindications

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