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pooled comparators found in a meta-analysis covering the whole clinical trial program, and the upper bounds of the confidence intervals for MACE were 8.5% [37]the latter results showing meaningful reductions in both subgroups, but with higher baseline HbA 1c predicting greater reductions

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As patients lose weight, they often report: Improved mobility and reduced joint discomfort Better sleep quality and reduced sleep apnoea symptoms Improved exercise tolerance Improved mood and psychological wellbeing Some patients may experience reduced inflammatory markers (such as C-reactive protein) as metabolic health improves