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Discontinuation rates due to AEs were 12.2% and 18.2% with Retatrutide 9 mg and 12 mg, respectively, compared to 4% with placebo

The bigger message is that these agents are pushing us toward a more integrated cardiometabolic model of care, in which obesity, heart failure, kidney disease, liver disease, and vascular risk are treated as connected biology rather than asseparate silos.

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