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Description
While there is no definitively established direct mechanism by which GLP-1 receptor agonists cause fatigue, several biological pathways warrant consideration

It is a series of medical decisions based on the patients progress, tolerance, risks, goals, and health markers

Factors such as side effect profiles, coexisting medical conditions, access, and cost must be considered
Notably, nearly 50% of the retatrutide phase 2 obesity trial were men, which is higher than in phase 3 clinical trials with tirzepatide (32.5% in SURMOUNT-1 [27]) and semaglutide 2.4 mg (25.9% in STEP-1 [8])
