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Food is community, tradition and lineage, and GLP-1s generally make a user largely food-proof

While one of the trials evaluated Orforglipron versus Dapagliflozin in 962 patients with type-2 diabetes inadequately controlled on Metformin, the other trial assessed Orforglipron versus placebo in 546 adults with type 2 diabetes and inadequate glycemic control with titrated insulin glargine

For adults with type 2 diabetes and established atherosclerotic cardiovascular disease, high cardiovascular risk, chronic kidney disease, or heart failure, guidelines recommend GLP-1 agonists with proven cardiovascular benefit as preferred agents, independent of metformin use or baseline A1C

The test reveals genetic variants in GLP1R (rs6923761), GIPR (rs1800437), and obesity-related genes without guaranteeing exact medication response