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Combination therapy with SGLT2 inhibitors + GLP-1 RAs may reduce cardiorenal risk and CV & all-cause mortality in T2D vs SGLT22 inhibitor and GLP-1 RA monotherapy
Chromium: Helps regulate glucose metabolism and maintain healthy blood sugar levels already within normal ranges, aiding in metabolic balance
In contrast, no benefits on the rate of decline in glomerular filtration rate have been seen in trials of DPP-4 inhibitors, perhaps because the renal actions of DPP-4 inhibitors are primarily mediated by potentiation of SDF-1, not GLP-1
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