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10.1038/s41598-021-88612-x 37 KazankovK.JrgensenS
Side effects comparison table What happens when you stop each medication This is where the conversation shifts from theoretical to deeply practical

Some patients carry genetic variants that reduce how effectively their GLP-1 receptors respond to the medication, leading to what researchers call 'primary non-response.' Others develop tolerance as their bodies adapt to the drug over weeks or months, a phenomenon called 'tachyphylaxis.' Lifestyle factors also play a measurable role

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