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Description
Mechanisms underlying metformin-induced secretion of glucagon-like peptide-1 from the intestinal L cell

So far, Novo Nordisks oral semaglutide and Lillys orforglipron are available

In patients with T2D in a phase 2 clinical trial, retatrutide (0.5 to 12 mg) significantly reduced body weight and HbA1c levels compared to placebo and 1.5 mg dulaglutide

More severe reactions could include difficulty breathing, swelling of the face, lips, tongue, or throat, which would require immediate emergency medical treatment