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As evidenced above, GLP-1 analogs are a great option for type-2 diabetics to help control postprandial and fasting plasma glucose levels not only through sensitizing beta-cells to plasma glucose and its effects on satiety and gastric emptying but also suppressing glucagon production to decrease hepatic glucose production

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However, the regulatory pathway did not include prediabetes as an approved indication, meaning pharmaceutical companies have not submitted the evidence package needed for insurers to authorize off-label use in that earlier disease stage