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The most common early side effects are gastrointestinal including nausea, vomiting, and diarrhoea consistent with other GLP-1-containing therapies

Xiao Y, Yang C, Yu L, Tian F, Wu Y, Zhao J et al (2021) Human gut-derived B

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Short-acting GLP-1RAs (exenatide [ t 1/2 of 2.4 hours] and lixisenatide [ t 1/2 of 24 hours] administered before meals twice-daily and once-daily, respectively) exhibit intermittent GLP-1 receptor activation translating into potent deceleration of upper gastrointestinal motility, an effect which is sustained during prolonged treatment