case report aspiration during anesthesia glp-1 receptor agonist 2023 Are Serious Risks of Semaglutide and Other Agonists Under-Recognized? Reports of Retained Solid Gastric Contents in Patients Undergoing Anesthesia Perioperative Use of GLP-1 Receptor

Serious side effects are still very rare, but people who have had medullary thyroid cancer or have a family history of it are not eligible because of the possible risks that come with GLP-1 receptor agonism

Each of these receptors, when activated, triggers distinct downstream cellular responses related to insulin secretion, glucose metabolism, appetite regulation, and energy homeostasis

There is evidence showing that GLP-1RAs can reduce the expression of cell apoptotic markers Bcl-2-associated x (Bax) and caspase-3 while upregulating Bcl-2 [99, 100], as well as protecting against lipotoxic stress via phosphoinositide 3-kinase (PI3K)/Akt/forkhead box proteins O1 (FoxO1) pathway [101]

In the case of I-M-150847, despite reduced cAMP generation, GSIS is comparable to liraglutide