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Since its clinical application in 1957, metformins cornerstone status has remained consistent and it is still the first-line preferred treatment for type 2 diabetes mellitus (T2DM) side by side with lifestyle (Montvida et al., 2018

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But today was not a failure of the data, it was a failure of the delivery.

Symptomatic relief can be achieved with over-the-counter treatments such as: Benzydamine mouthwash or spray for pain relief Protective gels containing hyaluronic acid or carmellose to coat ulcers Chlorhexidine mouthwash to reduce secondary bacterial infection (use short-term only, typically for 7 days, as it can cause staining and taste disturbance