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The cost difference reflects efficient direct-to-consumer business models, absence of brand-name marketing expenses and patent premiums, and streamlined distribution without multiple middlemen adding markups

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For perspective, prior to 2023, the top-selling drugs were largely immunology or oncology biologics (like Humira, Keytruda, Eliquis), but by mid-2024, the list transformed GLP-1 agonists entered the top ranks

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