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Description
Patients with certain rs6923761 polymorphisms may experience more pronounced initial gastrointestinal effects, though this typically diminishes with dose titration

For patients on weekly dosing (irrespective of indication, dose, or type of surgery), consider holding the GLP-1 agonist a week prior to procedure/surgery

By week four at each dose, side effects generally diminish substantially while weight loss benefits stabilize and become noticeable
Our goal is never long-term restriction or elimination
