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This primarily appears to be due to clinical results since GLP-1s lower A1C, reduce weight, improve cardiovascular outcomes, and potentially many other benefits

Furthermore, these agents modulate inflammation, reduce apoptosis, and improve stem cell functions even under diabetic or inflammatory conditions

Merola, M.D

Combining spironolactone with GLP-1 medications like semaglutide requires careful medical oversight due to potential effects on kidney function and electrolyte balance
