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They also underline the importance of an accurate diagnosis, firstly of lipedema and secondly of all comorbidities, to endorse multidisciplinary management of the patient, which has to include an endocrinemetabolic point of view

Methods High-fat diet (HFD)-induced obese rats were randomized into following treatment groups: group 1, nonselective PYY analog + semaglutide ( n = 4)

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Head-to-head data from the SURPASS-2 trial published in the New England Journal of Medicine demonstrates Mounjaros superiority: A1C reductions of -2.3% versus -1.9% for semaglutide, plus approximately three times greater weight loss (22 lb vs 7 lb at comparable doses)