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The body has to do something else with those signals, and for many this can lead to an increase in anxiety, depression or other negative emotions

lower emotional connection with providers

doi: 10.1007/s00401-003-0766-2 [DOI] [PubMed] [Google Scholar] 114.Ferrario CR, Reagan LP

-arrestins were first recognized for desensitizing GPCRs by uncoupling them from G-proteins and promoting receptor internalization via clathrin-coated pits, but are now known to act as signaling scaffolds themselves, initiating distinct pathways like ERK, JNK, or NF-B activation
