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10.1146/annurev-animal-111523-102249 Annu Rev Anim Biosci

Discussion It has been widely accepted that class B1 GPCRs adopt a two-step model for ligand binding and receptor activation 34,43

Known as GLP-1 receptor agonists, the drugs have soared in popularity in recent years, but patient access has been a consistent problem because of their cost around $500 a month for higher doses and insurance coverage has been spotty

Clinical evidence suggests that whilst these medicines do not directly damage the eyes, they may be associated with worsening diabetic retinopathy in certain patients, particularly those with pre-existing eye disease who experience rapid improvements in blood glucose control