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In 2024, the FDA approved resmetirom (Rezdiffra) for adults with noncirrhotic NASH with F2F3 fibrosis, marking the first approved pharmacotherapy specifically for this condition

Tirzepatide utilizes a dual synthetic hormone approach that generally shows better weight loss and blood sugar management

According to the semaglutide brand Ozempic, serious side effects include: Inflammation of your pancreas (pancreatitis) Changes in vision Low blood sugar (hypoglycemia) Kidney problems (kidney failure) Serious allergic reactions Gallbladder problems Clinical studies on Semaglutide and breastfeeding are limited, necessitating further studies to understand its potential risks and long-term effects comprehensively

Response, tolerance, and long-term adherence often matter more than the initial selection