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If semaglutide causes stress on the body (such as through nausea or blood sugar changes), it might lead to higher cortisol levels

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Supplements and Herbal Products to Avoid During GLP-1 Therapy Certain supplements can amplify nausea, vomiting, or gastrointestinal distressside effects already possible with semaglutide injection

Some patients find that eating a light meal before injecting (rather than on an empty stomach) helps reduce nausea this is a pragmatic measure based on patient experience rather than clinical trial evidence, and should be discussed with your prescriber