retatrutide clinical trials latest New Phase 3 data just dropped 👀 Eli Lilly's trial reported average weight loss approaching 30%, with some patients achieving results historically associated with bariatric surgery. A few important caveats 💉𝗥𝗲𝘁𝗮𝘁𝗿𝘂𝘁𝗶𝗱𝗲'𝘀 𝗨𝗻𝗲𝘅𝗽𝗲𝗰𝘁𝗲𝗱 𝗦𝗶𝗱𝗲 𝗘𝗳𝗳𝗲𝗰𝘁: 𝗪𝗵𝗮𝘁

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Its also worth noting that some patients experience new or worsened musculoskeletal symptoms during rapid weight loss, particularly if muscle mass isnt being preserved through adequate protein intake and resistance training

However, whereas single mutations of Y305 5.35b , L307 5.37b , and I308 5.38b to Ala did not significantly alter GLP-1 pharmacology in one study (Dods and Donnelly, 2015), the individual substitutions of Y305 5.35b and L307 5.37b with Ala resulted in 79-fold decreased affinity with 40-fold reduced potency and 13-fold reduced affinity with 25-fold lowered potency (Log c = 0.49), respectively, in a second (Koole et al., 2012a)

This precautionary measure protects patients from potentially serious complications, including aspiration pneumonia