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Electron microscopy revealed additional changes in patients with idiopathic gastroparesis, including damaged cell bodies, mitochondria, and nerve endings [37], whereas in diabetic gastroparesis, neuronal injury was less prominent and primarily affected the nerve endings, sparing the nerve bodies

Rare events, by definition, do not show up in small trials

Neurogenesis in Depression and Its Relation to GLP-1 In the brain, neurogenesis is a critical repair response against stress and age (Dranovsky et al., 2011)

Placebo-controlled trials similarly suggested higher effectiveness of tirzepatide, but study designs differed so results were not directly comparable, Rodriguez said