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Could GLP-1 agonists be the answer they are looking for

Regular use may help maintain ongoing support for natural GLP-1 hormone activation, sustain beneficial gut bacteria populations and microbiome diversity, promote continued appetite control and healthy glucose balance and support long-term metabolic wellness and digestive comfort

This indicates that it is the intra islet, -cell derived GLP-1 that shows the meal-induced insulinotropic properties

GLP-1 and analogs increase glucose consumption in mature cells whereas they reduce it in progenitor cells and ADSCs, which can lead to decreased production of ATP and energy deficiency
