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10.3390/pharmaceutics15010229 [DOI] [PMC free article] [PubMed] [Google Scholar] Leamy A

95% CI 0.74, 1.08

The increase in rate coincides with a steeper diastolic depolarization potential, shortening of the action potential duration, and a shift in the leading pacemaker site, all changes previously associated with a variety of neurohumoral factors 6769 but here identified to be independent of these

This is the same principle that makes hemoglobin in your blood appear red, though the specific metal and ring structure differ
