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Side Effects Profile All three medications share common side effects, primarily gastrointestinal: Nausea (usually temporary, worst in first few weeks) Diarrhea or constipation Abdominal discomfort Reduced appetite (this is the goal, but can feel uncomfortable initially) The higher dose of Wegovy may cause more pronounced side effects initially, while Saxendas daily dosing can offer more stable blood levels with potentially fewer ups and downs

Medical Students for Size Inclusivity have created an excelled GLP-1 informed consent guide here

Each carries distinct trade-offs in cost, convenience, regulatory status, and level of clinical oversight

AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B