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These include: Gallstones and gallbladder issues, thought to be caused by rapid weight loss Pancreatitis studies have shown a higher risk for this condition while taking GLP-1 medications compared to other weight loss medications Gastroparesis (delayed stomach emptying) though these medications are designed to slow down digestion, if it slows down too much, it can lead to other symptoms and complications

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The tert-butyl moiety of compound 2 points to TM7 and makes hydrophobic contacts with A350 6.39b and K351 6.40b , replacement at C-3 position by polar functional groups caused dramatic decline in its potency and efficacy 38

These GLP-1 receptor agonists, initially developed to treat diabetes, are now being hailed as breakthrough tools for weight loss