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This design yields a ~1-week half-life while preserving high affinity and selectivity for GLP-1R

Here we report the electron microscopy structure of the human GLP-2R in complex with GLP-2 and a Gs heterotrimer

Semaglutide is a long-acting GLP-1 receptor agonist that effectively lowers blood glucose, reduces HbA1c, and promotes weight loss
