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This article examines the evidence, safety considerations, and practical guidance for patients taking methotrexate who are considering weight loss injections

If you experience serious side effects such as allergic or hypersensitivity reactions and severe hypoglycemia (which can lead to coma), immediately visit a nearby healthcare facility

Abrupt cessation of Ozempic is not generally recommended without consulting a healthcare provider due to the risk of weight regain and the re-emergence of poor cardiometabolic control

For context on why dosing matters for this peptide, see our GLP-3 peptide guide which explains retatrutide's mechanism