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Main text Within this review, we provide an overview of the intricate interplay between chronic inflammation of the adipose tissue and the hypothalamus and the development of obesity
The glucagon-like peptide-1 receptor agonist (GLP-1 RA) is already approved for use in the treatment of obesity and for weight management
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metformin and dipeptidyl peptidase 4 inhibitors (DPP-4is) also significantly improved cognitive outcomes
