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GLP-1 (7-36) has a short half life of less than 2 minutes, and like GIP, is rapidly degraded by the enzyme dipeptidyl peptidase IV (DPP-4), which is widely expressed in a number of sites, including the endothelial cells of small gut arterioles
Tirzepatide takes approximately 20 weeks to reach 15 mg if following standard escalation with intermediate steps, while retatrutide reaches 12 mg in about 16 weeks
Some compounded products use semaglutide salts, which differ chemically from the base form studied in FDA trials
