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A critical analysis of recent literature highlights the importance of integrative and cautious approaches that account for the developmental plasticity of the pediatric organism and the possible pleiotropic effects of early pharmacological intervention.

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Although rare, associations with nonarteritic anterior ischemic optic neuropathy, pancreatitis, medullary thyroid carcinoma, and acute kidney injury (AKI) have been reported, primarily through pharmacovigilance and case-based evidence

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