how to wean off of semaglutide taper for weight loss safely How to Safely Stop Wegovy:

Older adults (65+) and those taking certain antihypertensive drugs may experience greater sensitivity to semaglutide's cardiovascular effects

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J.et al (2020)

18 With continued efforts in the development of newer antidiabetic agents, unimolecular GLP1R/GIPR dual agonists (twincretins) can provide added efficacy, especially among obese individuals with T2DM