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Immunol Cell Biol (2011) 89(1):13042
The classification of HF according to ejection fraction (EF) has been updated to include HF with reduced ejection fraction (HFrEF

Trial participants reported more frequent side effects, such as nausea, vomiting, and gastrointestinal discomfort, with some experiencing more adverse events

Starting even lower and escalating even more gradually should theoretically produce even fewer symptoms, at the cost of a longer time to reach therapeutic levels
