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Optimizing outcomes with GLP-1 medications requires a comprehensive approach that extends beyond simply taking the medication

Discontinuing either medication often results in weight regain, highlighting that obesity is a chronic disease requiring ongoing management

The inclusion criteria explicitly excluded people with diabetes to isolate weight loss effects in the non-diabetic obese population

GLP-1 receptor agonists such as semaglutide work by stimulating the pancreas to release insulin when blood sugar levels rise, while also reducing the levels of glucagon, a hormone that increases blood sugar
