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It is primarily cleared through receptor-mediated endocytosis and proteolytic degradation, not through hepatic CYP450 metabolism

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Glucagons Dual Role Glucagon is typically associated with raising blood glucose (it counteracts insulin), which is why adding a glucagon agonist to a diabetes treatment might seem counterintuitive

5 mg weekly for weeks 58 7.5 mg weekly for weeks 912 10 mg weekly for weeks 1316 12.5 mg weekly for weeks 1720 15 mg weekly as the maximum maintenance dose Timing: You can inject Zepbound any time of day, with or without food , just try to stick to the same day each week