The People v. Microdosing GLP-1's
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Description
Increases in the pulse rate were detected at the two highest tirzepatide doses in the T2D trial (+8.82 bpm for 10 mg and +9.8 bpm for 15 mg vs 3.81 bpm for placebo), comparable to the increase in the pulse rate (+11.2 bpm) seen with dulaglutide in healthy subjects
Contacts for further information References: Ozempic (semaglutide) Tablet [package insert]
This rebound is likely driven by increased food intake following drug discontinuation
Microdosing reduces exposure intensity, not receptor identity
