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Description
Long-term users (beyond 12 weeks) rarely report the same intensity of side effects as newcomers, though individual variation exists

Concerning aging, she said, there may well be some differences in the bloodbrain barrier between young mice and very old mice, but she is not sure they could be detected with the methods she currently uses
Nicholls SJ, Pavo I, Bhatt DL, et al

The longer the half-life, the longer the drug stays active in your systemand the less frequently you may need to inject
