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During that time the management of obesity and Type 2 diabetes (T2DM)the kind that usually is caused by being overweightoften felt like Sisyphus pushing a boulder up a hill, only to have it roll back down, often heavier than before

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Both incretin hormones exert a glucose-lowering action through two distinct yet structurally related class B G-protein-coupled receptors expressed in most pancreatic cells

Rats were individually housed at 22 C on a reverse light:dark cycle (dark from 11:00 to 23:00 h), and provided with ad libitum access to 45% HFD (D12451, Research Diets, Inc., USA) and drinking water