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But before we go down that path, one of the other things that has come out is that GLP-1s do seem to have other knock-on effects beyond weight loss and beyond diabetes, and so can you talk a little bit about some of the potential of GLP-1s for other health conditions

Taken together, such evidence strengthens the argument that tirzepatide should carry an explicit warning for bowel obstruction as a potential adverse effect, particularly given its increasing use in diabetes and obesity management

While healthy fibroblasts maintain healthy tissue structure, pro-fibrotic fibroblasts support fibrosis

Doses increase gradually over weeks, allowing your body to adapt