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Reduced levels of certain sirtuins resulting from decreased nicotinamide adenine dinucleotide (NAD+) may underlie the dysregulation of the aforementioned signaling pathways and therefore represent a potential therapeutic target

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Complications: *Blood clots* *Stroke* *Heart attack* *Organ damage* GLP-1 Receptor Agonists: A Promising Treatment for Polycythemia Vera Glucagon-Like Peptide-1 (GLP-1) receptor agonists have shown significant promise in treating polycythemia vera (PV), a rare blood disorder characterized by excessive production of red blood cells